Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BNIP3 |
| Gene Name: | BNIP3 |
| Protein Full Name: | BCL2/adenovirus E1B 19 kDa protein-interacting pro |
| Mass (Da): | 21541 |
| Number AA: | 194 |
| UniProt ID: | Q12983 |
| Locus ID: | 664 |
| COSMIC ID: | BNIP3 |
| Gene location on chromosome: | 10q26.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19719 |
| Percent of cancer specimens with mutations: | 0.18 |
| Normal role description: | BNIP3 plays a role in necrosis-like apoptosis and autophagy. It is induced by hypoxia via HIF-1. Its function leads to opening of mitochondrial permeablility transition pore resulting loss of proton electrochemical gradient and inducin apoptosis. Apoptosis can occur in the presence of Bcl-2, a suppressor of apoptosis. Other roles include repartitioning of calcium within the cell. |