Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IL24 |
| Gene Name: | IL24 |
| Protein Full Name: | Interleukin-24 |
| Alias: | Melanoma differentiation-associated gene 7 protein;Suppression of tumorigenicity 16 protein |
| Mass (Da): | 23825 |
| Number AA: | 206 |
| UniProt ID: | Q13007 |
| Locus ID: | 11009 |
| COSMIC ID: | IL24 |
| Gene location on chromosome: | 1q32 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.21 |
| Commentary on involvement of protein in cancer: | This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. |