Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Tiam1 |
| Gene Name: | TIAM1 |
| Protein Full Name: | T-lymphoma invasion and metastasis-inducing protei |
| Alias: | T-cell lymphoma invasion and metastasis 1; TIAM-1; T-lymphoma invasion and metastasis inducing protein 1 |
| Mass (Da): | 177508 |
| Number AA: | 1591 |
| UniProt ID: | Q13009 |
| Locus ID: | 7074 |
| COSMIC ID: | TIAM1 |
| Gene location on chromosome: | 21q22.1; 21q22.11 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20214 |
| Percent of cancer specimens with mutations: | 2.02 |
| Normal role description: | TIAM1 is a regulator of RHO-like proteins and connects extracellular signals to cytoskeletal activities. It also functions as a guanine nucleotide exchange factor (GEF). It's role in oncogenesis is unclear as it is found to be upregulated and downregulated in various neoplasms. Mutations in this gene have been observed in colon and ovarian tumors. |