Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STK4 |
| Gene Name: | STK4 |
| Protein Full Name: | Serine/threonine-protein kinase 4 |
| Alias: | EC 2.7.11.1; Kinase MST1; Kinase responsive to stress 2; KRS2; Krs-2; Mammalian sterile 20-like 1; MST1; MST-1; Serine,threonine protein kinase 4; Serine/threonine kinase 4; Serine/threonine protein kinase 4; Serine/threonine protein kinase Krs-2; STE20-like kinase MST1; Yeast Sps1,Ste20-related kinase 3; Yeast Sps1/Ste20-related kinase 3; Yeast Ste20-like; YSK3 |
| Mass (Da): | 55630 |
| Number AA: | 487 |
| UniProt ID: | Q13043 |
| Locus ID: | 6789 |
| COSMIC ID: | STK4 |
| Gene location on chromosome: | 20q11.2-q13.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 20261 |
| Percent of cancer specimens with mutations: | 0.31 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | STK4 is a serine-threonine kinase that is stress-activated and promotes apoptosis by inducing chromatin condensation followed by DNA fragmentation, possibly through the Hippo pathway. It also leads to the inactivation of the YAP1 oncoprotein by activating downstream proteins to prevent YAP1 from translocating to the nucleus and transcribing cell proliferation and migration genes. STK4 can also promote apoptosis by preventing the deacetylation of p53/TP53, thus promoting p53-dependent transcription and apoptosis. It is also able to inhibit the PKB/AKT1 pathway. |