Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MKRN3 |
| Gene Name: | MKRN3 |
| Protein Full Name: | Probable E3 ubiquitin-protein ligase makorin-3 |
| Alias: | D15S9; RING finger protein 63; RNF63; ZFP127; Zinc finger protein 127; ZNF127 |
| Mass (Da): | 55645 |
| Number AA: | 507 |
| UniProt ID: | Q13064 |
| Locus ID: | 7681 |
| COSMIC ID: | MKRN3 |
| Gene location on chromosome: | 15q11-q13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20121 |
| Percent of cancer specimens with mutations: | 1.26 |
| Normal role description: | MKRN3 encodes for a E3 ubiquitin ligase that catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins. |