Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ACACA |
| Gene Name: | ACACA |
| Protein Full Name: | Acetyl-CoA carboxylase 1 |
| Alias: | ACAC; ACC; ACC1; ACCA; ACC-alpha; Acetyl-Coenzyme A carboxylase alpha; COA1 |
| Mass (Da): | 265554 |
| Number AA: | 2346 |
| UniProt ID: | Q13085 |
| Locus ID: | 31 |
| COSMIC ID: | ACACA |
| Gene location on chromosome: | 17q21 |
| Cancer protein type: | TSP (possible) |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 7119 |
| Percent of cancer specimens with mutations: | 1.56 |
| Normal role description: | ACACA is a complex multifunctional enzyme system that catalyzes the rate-limiting reaction in the synthesis of long-chain fatty acids. Missense mutations in this gene have linked to large-intestine cancer. |
| Commentary on involvement of protein in cancer: | Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. |