Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | USP4 |
| Gene Name: | USP4 |
| Protein Full Name: | Ubiquitin carboxyl-terminal hydrolase 4 |
| Alias: | Deubiquitinating enzyme 4; Ubiquitin specific peptidase 4 (proto-oncogene); Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4; Ubiquitous nuclear protein homolog; UBP4; UNP; UNPH |
| Mass (Da): | 108565 |
| Number AA: | 963 |
| UniProt ID: | Q13107 |
| Locus ID: | 7375 |
| COSMIC ID: | USP4 |
| Gene location on chromosome: | 3p21.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20149 |
| Percent of cancer specimens with mutations: | 0.62 |
| Normal role description: | Protease that deubiquitinates target proteins such as the receptor ADORA2A and TRIM21. Regulates quality control in the ER. Expression levels elevated in some lung tumors. |