Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRAF3 |
| Gene Name: | TRAF3 |
| Protein Full Name: | TNF receptor-associated factor 3 |
| Alias: | CAP-1;CD40 receptor-associated factor 1;CD40-binding protein;LMP1-associated protein 1 |
| Mass (Da): | 64490 |
| Number AA: | 568 |
| UniProt ID: | Q13114 |
| Locus ID: | 7187 |
| COSMIC ID: | TRAF3 |
| Gene location on chromosome: | 14q32.33 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20394 |
| Percent of cancer specimens with mutations: | 0.49 |
| Normal role description: | Involved in B cell survival. Regulates pathways leading to the activation of NF-kappa-B and MAP kinases. Plays a role in the regulation of antiviral and T cell dependent immune response . Component of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity. Inhibits activation of NF-kappa-B in response to LTBR stimulation and TRAF2-mediated activation of NF-kappa-B. Promotes degradation of MAP3K14 via ubiquitination. Associated with Hodgkin lymphomas. |