Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PAK1 |
| Gene Name: | PAK1 |
| Protein Full Name: | Serine/threonine-protein kinase PAK 1 |
| Alias: | ADRB2; Alpha-PAK; CDC42,RAC effector kinase PAK-A; CDC42/RAC effector kinase PAK-A; EC 2.7.11.1; Kinase PAK1; MUK2; P21 protein (Cdc42/Rac)-activated kinase 1; P65-PAK; P68-PAK; PAK 1; PAK-1; PAKA; Protein kinase MUK2; STE20, yeast |
| Mass (Da): | 60647 |
| Number AA: | 545 |
| UniProt ID: | Q13153 |
| Locus ID: | 5058 |
| COSMIC ID: | PAK1 |
| Gene location on chromosome: | 11q13.5 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20451 |
| Percent of cancer specimens with mutations: | 0.45 |
| Normal role description: | PAK1 is a protein-serine/threonine kinase. Pak1 binds to activated forms of the GTPases Cdc42 and Rac. Upon binding to Cdc42 or Rac, Pak1 is activated and autophosphorylates. Pak1 has dozens of substrates, activating cytoskeletal and transcription pathways that enhance cell motility, proliferation, and survival. |