Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: STK3
Gene Name: STK3
Protein Full Name: Serine/threonine-protein kinase 3
Alias: EC 2.7.11.1; Krs-1; MESS1; Serine,threonine protein kinase 3; STK3
Mass (Da): 56301
Number AA: 491
UniProt ID: Q13188
Locus ID: 6788
COSMIC ID: STK3
Gene location on chromosome: 8q22.2
Cancer protein type: TSP
Effect of cancer mutation on protein: LOSS
Effect of active protein on cancer: INHIBITS
Number of cancer specimens: 20473
Percent of cancer specimens with mutations: 0.4
Normal role description: STK3 is a serine/threonine kinase that is induced by stress to carry out pro-apoptotic signalling. Once STK3 is activated by caspase-cleavage, it enters the nucleus where it then induces chromatin condensation followed by inter-nucleosomal DNA-fragmentation.STK3 also play a critical role in controlling organ size and tumors suppression by inhibiting proliferation and promoting apoptosis. Mutations in this gene have been observed in head and neck (pharynx) cancer.


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