Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PSMD2 |
| Gene Name: | PSMD2 |
| Protein Full Name: | 26S proteasome non-ATPase regulatory subunit 2 |
| Alias: | 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; TRAP2; Tumor necrosis factor type 1 receptor-associated protein 2 |
| Mass (Da): | 100200 |
| Number AA: | 908 |
| UniProt ID: | Q13200 |
| Locus ID: | 5708 |
| COSMIC ID: | PSMD2 |
| Gene location on chromosome: | 3q27.1 |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.55 |
| Commentary on involvement of protein in cancer: | Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Binds to the intracellular domain of tumor necro |