Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DDX10 |
| Gene Name: | DDX10 |
| Protein Full Name: | Probable ATP-dependent RNA helicase DDX10 |
| Alias: | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10; DEAD box protein 10; HRH-J8 |
| Mass (Da): | 100888 |
| Number AA: | 875 |
| UniProt ID: | Q13206 |
| Locus ID: | 1662 |
| COSMIC ID: | DDX10 |
| Gene location on chromosome: | 11q22-q23 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20301 |
| Percent of cancer specimens with mutations: | 0.57 |
| Normal role description: | DDX10 encodes for a DEAD-box protein. These proteins, characterized by their conserved Asp-Glu-Ala-Asp (DEAD)-sequence, are putative ATP-dependent RNA helicases. Suggested to be involved in ribosome assembly. Inversion found in MDS and ANLL: inv (11)(p15q22), resulting in the fused gene NUP98-DDX10. |