Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TBX2 |
| Gene Name: | TBX2 |
| Protein Full Name: | T-box transcription factor TBX2 |
| Alias: | T-box 2; T-box protein 2 |
| Mass (Da): | 74068 |
| Number AA: | 702 |
| UniProt ID: | Q13207 |
| Locus ID: | 6909 |
| COSMIC ID: | TBX2 |
| Gene location on chromosome: | 17q23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.42 |
| Normal role description: | Transcription factor upregulated in different cancer systems. Has been demonstrated to inhibit the expression of CDKN1A. TBX2 is shown to repress the CDKN2A promoter and also attenuate the induction of CDKN2A by E2F1, MYC, and HRAS, providing senescence bypass. Therefore, overexpression TBX2 confers imortality to cells and promotes tumour progression. |