Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ERCC8 |
| Gene Name: | ERCC8 |
| Protein Full Name: | DNA excision repair protein ERCC-8 |
| Alias: | Cockayne syndrome WD repeat protein CSA |
| Mass (Da): | 44055 |
| Number AA: | 396 |
| UniProt ID: | Q13216 |
| Locus ID: | 1161 |
| COSMIC ID: | ERCC8 |
| Gene location on chromosome: | 5q12.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19806 |
| Percent of cancer specimens with mutations: | 0.24 |
| Normal role description: | ERCC8 interacts with cockayne syndrome groube B protein and a subunit of RNA polymerase II transcripfactor IIH to form a CSA complex. It is involved in ubquintination and degradation of ERCC6 in a UV-dependent manner for recovery of RNA synthesis after transcription couples repair. |