Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SEMA3F |
| Gene Name: | SEMA3F |
| Protein Full Name: | Semaphorin-3F |
| Alias: | Sema III/F;Semaphorin IV |
| Mass (Da): | 88381 |
| Number AA: | 785 |
| UniProt ID: | Q13275 |
| Locus ID: | 6405 |
| COSMIC ID: | SEMA3F |
| Gene location on chromosome: | 3p21.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19814 |
| Percent of cancer specimens with mutations: | 0.65 |
| Normal role description: | Involved in tissue morphogenesis, direct axon migration and target connections, immune responses, cancer progression, metastasis and angiogenesis. Semaphorins affect the cytoskeleton and organization of actin filaments in addition to the microtubule network through receptor binding. Inhibits integrin activation and downstream pathways in lung cancer cells. Loss or dislocation in lung cancer and associated with LOH in breast cancer. |