Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTK7 |
| Gene Name: | PTK7 |
| Protein Full Name: | Tyrosine-protein kinase-like 7 |
| Alias: | Colon carcinoma kinase 4;Protein-tyrosine kinase 7 |
| Mass (Da): | 118392 |
| Number AA: | 1070 |
| UniProt ID: | Q13308 |
| Locus ID: | 5754 |
| COSMIC ID: | PTK7 |
| Gene location on chromosome: | 6p21.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20760 |
| Percent of cancer specimens with mutations: | 0.78 |
| Normal role description: | PTK7 is a protein-tyrosine kinase. Inactive tyrosine kinase involved in Wnt signalling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signalling) and the canonical Wnt signalling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis (UniProt quote). |