Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Grb10 |
| Gene Name: | GRB10 |
| Protein Full Name: | Growth factor receptor-bound protein 10 |
| Alias: | GRB10 adaptor protein; GRBIR; Insulin receptor binding protein GRB-IR; KIAA0207 |
| Mass (Da): | 67231 |
| Number AA: | 594 |
| UniProt ID: | Q13322 |
| Locus ID: | 2887 |
| COSMIC ID: | GRB10 |
| Gene location on chromosome: | 7p12-11.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20339 |
| Percent of cancer specimens with mutations: | 0.68 |
| Normal role description: | GRB10 is an adapter protein and a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the protein will lead to inhibition of tyrosine kinase activity and results in supression of growth. It exerts its regulatory effects by inhibiting signalling pathways and by increasing receptor degradation. It is responsible for delaying and reducing AKT1 phosphorylation in response to insulin stimulation and for blocking binding of INSR and IRS1 and IRS2, and for preventing insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. It recruits NEDD4 to IGF1R, leading to ubiquitination of the receptor and increased proteasomal degradation. It negatively regulates Wnt signalling, and is a positive regulator of the KDR/VEGFR-2 signalling pathway. Expression of the gene observed in the brain are from the paternal allele whereas the gene expression in the placental trophoblasts is from the maternal allele. |
| Commentary on involvement of protein in cancer: | 1 laryngeal sample (mis-sense) and 3/334 lung cancer samples (mis-sense) were also mutated |