Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MTA1 |
| Gene Name: | MTA1 |
| Protein Full Name: | Metastasis-associated protein MTA1 |
| Alias: | Full-length cDNA 5-PRIME end of clone CS0DK005YC03 of HeLa cells of Homo sapiens (human) |
| Mass (Da): | 80786 |
| Number AA: | 715 |
| UniProt ID: | Q13330 |
| Locus ID: | 9112 |
| COSMIC ID: | MTA1 |
| Gene location on chromosome: | 14q32.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19672 |
| Percent of cancer specimens with mutations: | 0.56 |
| Normal role description: | MTA1 may play a role in gene expression regulation by covalently modify histone proteins, altering chromatin structure and controlling transcription. One isoform ('Long') of the gene functions as a co-repressor of the estrogen receptor, and the other isoform ('Short') binds to and sequesters the receptor in the cytoplasm, thus enhancing non-genomic responses of ER. It was first identified in a screen for genes expressed in metastatic cells, and the expression of the gene has been correlated with the metastatic potential of at least two types of carcinomas. However, its exact role in metastasis remains unclear. |
| Commentary on involvement of protein in cancer: | 1/44 CNS samples was also mutated (Sanger COSMIC) |