Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MPP3 |
| Gene Name: | MPP3 |
| Protein Full Name: | MAGUK p55 subfamily member 3 |
| Alias: | Discs large homolog 3; Discs, large 3; DLG3; Membrane protein palmitoylated 3; Membrane protein, palmitoylated 3; Protein MPP3 |
| Mass (Da): | 66152 |
| Number AA: | 585 |
| UniProt ID: | Q13368 |
| Locus ID: | 4356 |
| COSMIC ID: | MPP3 |
| Gene location on chromosome: | 17q21.31 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.41 |
| Normal role description: | MPP3 is a membrane associated protein that contains a SH3 domain. MPP3 is known to interact with 5-HT4R (serotonin receptor), which upon 5HT binding induces the production of cAMP. This would results in increased activation of CREB by PKA, and as CREB induces transcription of Myc, thus MPP3 could act as an oncoprotein. |
| Commentary on involvement of protein in cancer: | May interact with HTR2A By similarity. Interacts (via PDZ domain) with CADM1 (via C-terminus). Interacts with HTR4 |