Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SLC39A6 |
| Gene Name: | SLC39A6 |
| Protein Full Name: | Zinc transporter ZIP6 |
| Alias: | Estrogen-regulated protein LIV-1; LIV1; LIV-1; S39A6; Solute carrier family 39 (zinc transporter) member 6; Zinc transporter ZIP6; Zrt- and Irt-like protein 6 |
| Mass (Da): | 85047 |
| Number AA: | 749 |
| UniProt ID: | Q13433 |
| Locus ID: | 25800 |
| COSMIC ID: | SLC39A6 |
| Gene location on chromosome: | 18q12.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19627 |
| Percent of cancer specimens with mutations: | 0.62 |
| Normal role description: | SLC39A6 is a transporter for zinc uptake in cells. SLC39A6 has been found to regulate transcription through promoting STAT3 signalling through the Snail transcription factor. SLC39A6 appears to be required for histone desactylase inhibit (TSA)-mediated apoptosis. |