Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ADAM9 |
| Gene Name: | ADAM9 |
| Protein Full Name: | Disintegrin and metalloproteinase domain-containin |
| Alias: | A disintegrin and metalloproteinase domain 9; ADAM metallopeptidase domain 9; Cellular disintegrin-related protein; Disintegrin and metalloproteinase domain-containing protein 9: Metalloprotease/disintegrin/cysteine-rich protein 9: Myeloma cell metalloproteinase: Meltrin-gamma: Cellular disintegrin-related protein; KIAA0021; MCMP; MDC9; Meltrin gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; Mltng; Myeloma cell metalloproteinase |
| Mass (Da): | 90556 |
| Number AA: | 819 |
| UniProt ID: | Q13443 |
| Locus ID: | 8754 |
| COSMIC ID: | ADAM9 |
| Gene location on chromosome: | 8p11.23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.61 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | ADAM9 is a widely expressed disintegrin, zinc metalloprotease and adhesion protein that is implicated in cell-cell or cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It also has the ability to digest extracellular matrix proteins such as fibronectin and laminin. It may have roles in MAPKK activation and TGF-β signalling. It can also cleave the ectodomains or membrane bound proteins and promote the secretion of such proteins such as amyloid precursor protein, insulin beta-chain, HB-EGF. It may exist as both a membrane bound protein or a secreted protein. Defects in ADAM9 has been associated with prostate, pancreatic, breast, lung, and renal cell carcinoma cancers. |