Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BIRC3 |
| Gene Name: | BIRC3 |
| Protein Full Name: | Baculoviral IAP repeat-containing protein 3 |
| Alias: | AIP1; API2; Apoptosis inhibitor 2; Baculoviral IAP repeat-containing 3; BIRC3; CIAP2; C-IAP2; HAIP1; HIAP1; HIAP-1; IAP homolog C; IAP1; Inhibitor of apoptosis protein 1; MALT2; Mammalian IAP C; MIHC; RNF49; TNFR2-TRAF signaling complex protein |
| Mass (Da): | 68372 |
| Number AA: | 604 |
| UniProt ID: | Q13489 |
| Locus ID: | 330 |
| COSMIC ID: | BIRC3 |
| Gene location on chromosome: | 11q21 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 22737 |
| Percent of cancer specimens with mutations: | 0.87 |
| Deregulated in translocations: | B cell Non Hodgkin Lymphoma, Fusion partner MLT |
| Normal role description: | Inhibits apoptosis probably via interfering with activation of caspase. |