Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BIRC2 |
| Gene Name: | BIRC2 |
| Protein Full Name: | Baculoviral IAP repeat-containing protein 2 |
| Alias: | API1; Apoptosis inhibitor 1; Baculoviral IAP repeat-containing 2; CIAP1; C-IAP1; IAP B; IAP2; Iap-2; Inhibitor of apoptosis protein 2; MIHB; NFR2-TRAF signalling complex protein; RING finger 48; RNF48; TNFR2-TRAF-signaling complex 2 |
| Mass (Da): | 69900 |
| Number AA: | 618 |
| UniProt ID: | Q13490 |
| Locus ID: | 329 |
| COSMIC ID: | BIRC2 |
| Gene location on chromosome: | 11q22.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20238 |
| Percent of cancer specimens with mutations: | 0.42 |
| Found in amplified chromosomal regions in human cancers: | squamous cell carcinomas of the esophagus and uterine cervix. |
| Normal role description: | BIRC2 is a widely expressed suppressor of apoptosis in cells. This protein will inhibit pro-apoptotic proteins such as tumour necrosis factor receptor-associated factors (TRAF), RIP1 and Smac/DIABLO leading to their subsequent ubiquitination and degradation. Overexpression of BIRC2 by amplification has been observed in cancers of the esophagus and uterine cervix. Cell lines from these cancer types have shown resisntance to radiation-induced cell death compared to wild-type controls. |