Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PRPF4B |
| Gene Name: | PRPF4B |
| Protein Full Name: | Serine/threonine-protein kinase PRP4 homolog |
| Alias: | CBP143; EC 2.7.11.1; KIAA0536; Kinase PRP4; PR4H; Pre-mRNA protein kinase; Prp4; PRP4 homolog; PRP4 kinase; PRP4 pre- mRNA processing factor 4 homolog; PRP4 pre-mRNA processing factor 4 B; PRP4B; PRP4H; PRP4K; PRP4M; PRPK |
| Mass (Da): | 116973 |
| Number AA: | 1007 |
| UniProt ID: | Q13523 |
| Locus ID: | 8899 |
| COSMIC ID: | PRPF4B |
| Gene location on chromosome: | 6p25.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20380 |
| Percent of cancer specimens with mutations: | 0.41 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PRPF4B is a serine/threonine protein kinase that can phosphorylate the splicing factor SF2/ASF and thus play a role in pre-mRNA splicing. Its role in cancer is not well known. |