Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ATR |
| Gene Name: | ATR |
| Protein Full Name: | Serine/threonine-protein kinase ATR |
| Alias: | EC 2.7.11.1; FRAP-related protein; FRP1 |
| Mass (Da): | 301367 |
| Number AA: | 2644 |
| UniProt ID: | Q13535 |
| Locus ID: | 545 |
| COSMIC ID: | ATR |
| Gene location on chromosome: | 3q23 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20325 |
| Percent of cancer specimens with mutations: | 1.83 |
| Normal role description: | ATR is a protein-serine/threonine kinase. It is part of the PI3K family and functions in a complex with ATRIP. It responds to DNA damage and replication stresses and activates proteins that mediate DNA repair such as p53, BRCA1 and more. It other roles involve checkpoint signalling by interacting with chk1, fragile site stabilty and regulation of centrosome duplication. |