Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MTMR3 |
| Gene Name: | MTMR3 |
| Protein Full Name: | Myotubularin-related protein 3 |
| Alias: | EC 3.1.3.48; FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; KIAA0371, ZFYVE10; Zinc finger FYVE domain-containing protein 10 |
| Mass (Da): | 133619 |
| Number AA: | 1198 |
| UniProt ID: | Q13615 |
| Locus ID: | 8897 |
| COSMIC ID: | MTMR3 |
| Gene location on chromosome: | 22q12.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19842 |
| Percent of cancer specimens with mutations: | 0.09 |
| Normal role description: | MTMR3 is a phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. It can therefore be speculated that MTMR3 will attenuate the pro-oncogenic signalling of IP3/AKT pathway but this has not been clearly demonstrated. |