Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CUL3 |
| Gene Name: | CUL3 |
| Protein Full Name: | Cullin-3 |
| Alias: | KIAA0617 |
| Mass (Da): | 88930 |
| Number AA: | 768 |
| UniProt ID: | Q13618 |
| Locus ID: | 8452 |
| COSMIC ID: | CUL3 |
| Gene location on chromosome: | 2q36.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19925 |
| Percent of cancer specimens with mutations: | 0.77 |
| Normal role description: | CUL3 is involved in mitosis signalling. CUL3/KLHL9/KLHL13 acted as an E3 ligase and regulated dynamic localization of the chromosomal passenger protein Aurora B. This complex is essential for the faithful propagation of genetic material to daughter cells. Role in oncogenesis unclear |