Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | THOC5 |
| Gene Name: | THOC5 |
| Protein Full Name: | THO complex subunit 5 homolog |
| Alias: | C22orf19; CV019; CV19; Fmip; Fms-interacting protein; FSAP79; Functional spliceosome-associated protein 79; HTREX90; KIAA0983; NF2/meningioma region protein pK1.3; PK1.3; Placental protein 39.2; THO complex 5; THO complex subunit 5 homolog: NF2/meningioma region protein pK1.3: Placental protein 39.2 |
| Mass (Da): | 78508 |
| Number AA: | 683 |
| UniProt ID: | Q13769 |
| Locus ID: | 8563 |
| COSMIC ID: | THOC5 |
| Gene location on chromosome: | 22q12.2 |
| Number of cancer specimens: | 20122 |
| Percent of cancer specimens with mutations: | 0.48 |
| Commentary on involvement of protein in cancer: | Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. DDX39B functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. |