Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NCOA4 |
| Gene Name: | NCOA4 |
| Protein Full Name: | Nuclear receptor coactivator 4 |
| Alias: | 70 kDa androgen receptor coactivator; ARA70; DKFZp762E1112; ELE1; Nuclear receptor coactivator 4 - PTC3 (ELE1); PTC3; RET-activating gene ELE1; RFG |
| Mass (Da): | 69726 |
| Number AA: | 614 |
| UniProt ID: | Q13772 |
| Locus ID: | 8031 |
| COSMIC ID: | NCOA4 |
| Gene location on chromosome: | 10q11.23 |
| Number of cancer specimens: | 23945 |
| Percent of cancer specimens with mutations: | 0.05 |
| Deregulated in translocations: | Papillary thyroid carcinoma. Fusion partners include RET |
| Normal role description: | NCOA4 interacts with androgen receptors in order to activate them. |