Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ENPP2 |
| Gene Name: | ENPP2 |
| Protein Full Name: | Ectonucleotide pyrophosphatase/phosphodiesterase f |
| Alias: | ATX; Ectonucleotide pyrophosphatase/phosphodiesterase 2; E-NPP 2; ENPP2; LysoPLD; NPP2; NPPase; PD-I alpha; PD-IALPHA; PDNP2; Phosphodiesterase I alpha; Phosphodiesterase I/nucleotide pyrophosphatase 2 |
| Mass (Da): | 99004 |
| Number AA: | 863 |
| UniProt ID: | Q13822 |
| Locus ID: | 5168 |
| COSMIC ID: | ENPP2 |
| Gene location on chromosome: | 8q24.12 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19989 |
| Percent of cancer specimens with mutations: | 1.14 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | ENPP2 is a phosphodiesterase and a phospholipase that can hydrolyze lysophopholipids (e.g. lysophosphatidylcholine) to produce lysophosphatidic acid. It can also act on sphingosylphosphorylcholine to produce sphingosine-1-phosphate, a modulator of cell motility. As such, it may regulate several other motility-related processes such as angiogenesis and neurite outgrowth. It has been shown to stimulate the migration of melanoma cells and possibly cell proliferation. As such, it has been called a tumour cell motility-stimulating factor. Overexpression of the protein in cancer cells has been noted and has been associated with motility and invasion, growth and metastasis, and angiogenesis. It appears to be more involved in cancer progression rather than initiation. |