Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTK6 |
| Gene Name: | PTK6 |
| Protein Full Name: | Protein-tyrosine kinase 6 |
| Alias: | Brk6; EC 2.7.10.2; PTK6; Tyrosine-protein kinase 6 |
| Mass (Da): | 51834 |
| Number AA: | 451 |
| UniProt ID: | Q13882 |
| Locus ID: | 5753 |
| COSMIC ID: | PTK6 |
| Gene location on chromosome: | 20q13.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20167 |
| Percent of cancer specimens with mutations: | 0.33 |
| Normal role description: | PTK6 is a protein-tyrosine kinase. It is a cytoplasmic nonreceptor protein-kinase that seems to function as an intracellular signal transducer in epithelial tissues. Upregulation of this gene in mammary epithelium causes sensitization to epidermal growth factor (EGF) and results in a partially transformed phenotype. Upregulation of this gene has been found in some breast cancers, while mutation in this gene have been found in skin, ovairan, and gastric tumors. |
| Commentary on involvement of protein in cancer: | Phosphorylates KHDRBS1, KHDRBS2, KHDRBS3 and STAP2/BKS. May function as an intracellular signal transducer in epithelial tissues. Overexpression in mammary cells leads to mitogenically sensitization to EGF, and results in a partially transformed phenotype. Its presence in the nucleus appears to be linked to suppression of tumor progression. |