Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KLF5 |
| Gene Name: | KLF5 |
| Protein Full Name: | Krueppel-like factor 5 |
| Alias: | Basic transcription element binding protein 2; BTEB2; BTE-binding protein 2; CKLF; Colon krueppel-like factor; GC box binding protein 2; IKLF; Intestinal-enriched krueppel-like factor; Kruppel-like factor 5 (intestinal) |
| Mass (Da): | 50792 |
| Number AA: | 457 |
| UniProt ID: | Q13887 |
| Locus ID: | 688 |
| COSMIC ID: | KLF5 |
| Gene location on chromosome: | 13q21.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.5 |
| Normal role description: | KLF5 is a transcription factor that bindes GC box promoter elements and induces transcription. KLF5 is known to upregulate cdk inhibitor p21(waf1/cip1) and the pro-apoptotic protein, BAX, after UV irradiation. Downregulation of this gene is associated with intestinal and colon cancer, as well as it complete absence (due to deletion) in bladder and breast cancers. |