Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RAPGEF1 |
| Gene Name: | RAPGEF1 |
| Protein Full Name: | Rap guanine nucleotide exchange factor (GEF) 1 |
| Mass (Da): | 122735 |
| Number AA: | 1095 |
| UniProt ID: | Q13905 |
| Locus ID: | 2889 |
| COSMIC ID: | RAPGEF1 |
| Gene location on chromosome: | 9q34.13 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20425 |
| Percent of cancer specimens with mutations: | 0.84 |
| Normal role description: | Interacts with many proteins involved in cellular signalling including p130Cas, Crk, Crk-L, Grb2, Hck, PDGF, Cas-L, Shc, Rap1, c-Abl, PP2A and E-cadherin. RAPGEF1 has a variety of different cellular outcomes depending on interaction partners. For example, RAPGEF1 inhibits the ERK signalling pathway but has also been shown to activate members of the Ras superfamily and also interact with c-abl. RAPGEF1 induces p21 cell-cycle arrest. Therefore, it can be speculated that this protein possess both pro- and anti- oncogenic proteins depending on which signalling pathways predominate. |