Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RasGRF1 |
| Gene Name: | RASGRF1 |
| Protein Full Name: | Ras-specific guanine nucleotide-releasing factor 1 |
| Alias: | CDC25; CDC25L; GNRP; GRF1; GRF55; Guanine nucleotide releasing protein; H-GRF55; P140 Ras-GRF; PP13187; Ras protein-specific guanine nucleotide-releasing factor 1; RASGRF1; Ras-specific nucleotide exchange factor CDC25; RGRF1 |
| Mass (Da): | 145383 |
| Number AA: | 1275 |
| UniProt ID: | Q13972 |
| Locus ID: | 5923 |
| COSMIC ID: | RASGRF1 |
| Gene location on chromosome: | 15q25.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20151 |
| Percent of cancer specimens with mutations: | 1.43 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | RASGRF1 is a guanine nucleotide exchange factor that activates H-Ras by exchanging GDP with GTP. Its expression is limited to the brain and synaptic junctions, which suggests that it does not play proliferative roles under normal physiologic conditions. It plays an important role in AMPA and NMDA receptor-mediated activation of the MAPK/ERK pathway in mature neurons, suggesting it may play a role in long term memory formation. Apart from H-Ras, it can also activate Rac if activated by the Gβγ subunits of the heterotrimeric G protein system. |