Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HNRNPD |
| Gene Name: | HNRNPD |
| Protein Full Name: | Heterogeneous nuclear ribonucleoprotein D0 |
| Alias: | ARE element RNA-binding protein AUF1; AUF1; AU-rich element RNA binding protein 1; AU-rich element RNA-binding protein 1; Heterogeneous nuclear ribonucleoprotein D; HNRPD; ROD |
| Mass (Da): | 38434 |
| Number AA: | 355 |
| UniProt ID: | Q14103 |
| Locus ID: | 3184 |
| COSMIC ID: | HNRNPD |
| Gene location on chromosome: | 4q21.22 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19557 |
| Percent of cancer specimens with mutations: | 0.21 |
| Normal role description: | HNRNPD is a nuclear ribonucleoprotein and transcription factor involved in the regulation of apoptosis, tumorigenesis, and development. It can bind both ssDNA and RNA, especially transcripts bearing AREs in their 3' UTR, and its over-expression strongly influences the stability of these mRNAs. The gene appears to increase the degradation of target mRNAs, especially mRNAs encoding mitogenic, immune- and cancer-associated, stress response-, and cell cycle regulatory proteins such as c-fos, c-jun, c-myc, interleukins, iNOS, p21, MnSOD, cyclin D1, and cdc25 to name a few. It has been found to be over-expressed in various cancers. |
| Commentary on involvement of protein in cancer: | The gene is also over-expressed in sarcomas |