Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EIF3A |
| Gene Name: | EIF3A |
| Protein Full Name: | Eukaryotic translation initiation factor 3 subunit |
| Alias: | EIF3; EIF3-p170; EIF3S10; EIF3-theta; Eukaryotic translation initiation factor 3 subunit 10; Eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa; Eukaryotic translation initiation factor 3, subunit A; IF3A; KIAA0139; P167; TIF32 |
| Mass (Da): | 166569 |
| Number AA: | 1382 |
| UniProt ID: | Q14152 |
| Locus ID: | 8661 |
| COSMIC ID: | EIF3A |
| Gene location on chromosome: | 10q26.11 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 1.07 |
| Mutations observed as inherited: | Two SNPs associated with higher risk of breast cancer |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | EIF3A plays a role in the eukaryotic translation initiation factor 3 complex required for protein synthesis initiation. The complex associates with the 40S ribosome and facilitates the recruitment of other initiation factors such as EIF1A to form the 43S preinitiation complex and stimulates mRNA recruitment to the preinitiation complex. EIF3A has been recognized as one of the 37 genes required for cell division. It has been found to be overexpressed in breast cancer tissues, gastric carcinoma, and lung cancer. |