Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SCRIB |
| Gene Name: | SCRIB |
| Protein Full Name: | Protein scribble homolog |
| Alias: | CRIB1; KIAA0147; LAP4; Protein scribble homologue; SCRB1; VARTUL |
| Mass (Da): | 174885 |
| Number AA: | 1630 |
| UniProt ID: | Q14160 |
| Locus ID: | 23513 |
| COSMIC ID: | SCRIB |
| Gene location on chromosome: | 8q24.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 1.13 |
| Normal role description: | Involved in cell differentiation. May play a role in proliferation regulating progression from G1 to S phase and act as a positive regulator of apoptosis. Suggested to be involved in cell migration via MAPK pathway, exocytosis and vesicle trafficking. Activates Rac. |