Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | WRN |
| Gene Name: | WRN |
| Protein Full Name: | Werner syndrome ATP-dependent helicase |
| Alias: | RECQ3; RECQL2; RECQL3; Werner syndrome (RECQL2); Werner Syndrome helicase; Werner syndrome, RecQ helicase-like |
| Mass (Da): | 162495 |
| Number AA: | 1432 |
| UniProt ID: | Q14191 |
| Locus ID: | 7486 |
| COSMIC ID: | WRN |
| Gene location on chromosome: | 8p12 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20789 |
| Percent of cancer specimens with mutations: | 1.06 |
| Normal role description: | Has DNA helicase and 3'->5' exonuclease activity towards double-stranded DNA with 5' overhang, but not blunt end dsDNA or single-stranded DNA. Binds preferentially to replication forks and Holliday junctions. May play a role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Implicated in Werner syndrome that is accompanied by development of various malignancies. |