Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GAS6 |
| Gene Name: | GAS6 |
| Protein Full Name: | Growth arrest-specific protein 6 |
| Alias: | AXL receptor tyrosine kinase ligand; AXL stimulatory factor; AXLLG; AXSF; DKFZp666G247; FLJ34709; GAS-6; Growth arrest-specific 6; Growth-arrest-specific protein 6 |
| Mass (Da): | 79680 |
| Number AA: | 721 |
| UniProt ID: | Q14393 |
| Locus ID: | 2621 |
| COSMIC ID: | GAS6 |
| Gene location on chromosome: | 13q34 |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.02 |
| Commentary on involvement of protein in cancer: | Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. |