Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HIC1 |
| Gene Name: | HIC1 |
| Protein Full Name: | Hypermethylated in cancer 1 protein |
| Alias: | Hic-1; Hypermethylated in cancer 1; ZBTB29; Zinc finger and BTB domain-containing protein 29 |
| Mass (Da): | 76468 |
| Number AA: | 733 |
| UniProt ID: | Q14526; O95459; Q70SM2 |
| Locus ID: | 3090 |
| COSMIC ID: | HIC1 |
| Gene location on chromosome: | 17p13.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19670 |
| Percent of cancer specimens with mutations: | 0.26 |
| Gene undergoes hypermethylation: | Hypermethylation of promoter in breast, ovary and prostate cancer. |
| Normal role description: | HIC1 is a site-specific transcriptional repressor protein. This protein is subject to post-translation modifications including acetylation and SUMOylation of lysine residues which regulates its activity. Deletion or repression of HIC1 has been implicated in medulloblastomas, breast, ovary and prostate cancer. HIC1 is suggested to have a tumour suppressor role. |