Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RASA3 |
| Gene Name: | RASA3 |
| Protein Full Name: | Ras GTPase-activating protein 3 |
| Alias: | GAP1(IP4BP); GAP1IP4BP; GAPIII; Ins P4-binding protein; RAS p21 protein activator 3 |
| Mass (Da): | 95699 |
| Number AA: | 834 |
| UniProt ID: | Q14644 |
| Locus ID: | 22821 |
| COSMIC ID: | RASA3 |
| Gene location on chromosome: | 13q34 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20173 |
| Percent of cancer specimens with mutations: | 0.75 |
| Normal role description: | Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. May therefore function as an inhibitor of Ras pathway oncogenesis except if oncogenesis is directly driven by Ras protein mutations or constituent activation occurs in downstream targets. |