Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PUM1 |
| Gene Name: | PUM1 |
| Protein Full Name: | Pumilio homolog 1 (Drosophila) |
| Alias: | Pumilio homolog 1; Pumilio homolog 1 (Drosophila), isoform CRAc; Pumilio homologue 1 (Drosophila), isoform CRA_c; Putative uncharacterized protein PUM1 |
| Mass (Da): | 130108 |
| Number AA: | 1224 |
| UniProt ID: | Q14671 |
| Locus ID: | 9698 |
| COSMIC ID: | PUM1 |
| Gene location on chromosome: | 1p35.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.9 |
| Normal role description: | PUM1 serves as a translational regulator of specific mRNAs by binding to their 3' UTR's. It may play a role in translational regulation of embryogenesis, cell development, and differentiation. |
| Commentary on involvement of protein in cancer: | 100% (1/1) of pharyngeal tumour samples were mutated (mis-sense) |