Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NCOA6 |
| Gene Name: | NCOA6 |
| Protein Full Name: | Nuclear receptor coactivator 6 |
| Alias: | Amplified in breast cancer protein 3 |
| Mass (Da): | 219145 |
| Number AA: | 2063 |
| UniProt ID: | Q14686 |
| Locus ID: | 23054 |
| COSMIC ID: | NCOA6 |
| Gene location on chromosome: | 20q11 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19881 |
| Percent of cancer specimens with mutations: | 1.57 |
| Found in amplified chromosomal regions in human cancers: | breast cancer (10%) |
| Normal role description: | NCOA6 encodes for a nuclear hormone receptor coactivator. Activates receptors for steroids, retinoids, thyroid hormone , vitamin D3 and prostanoids. May be involved in coactivation of the NF-kappa-B pathway. Suggested to coactivate expression via remodeling of chromatin and interaction with histone acetyltransferase proteins. |