Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KIAA0182 |
| Gene Name: | GSE1 |
| Protein Full Name: | Genetic suppressor element 1 |
| Alias: | GSE1; K0182; Y182 |
| Mass (Da): | 136164 |
| Number AA: | 1217 |
| UniProt ID: | Q14687 |
| Locus ID: | 23199 |
| COSMIC ID: | GSE1 |
| Gene location on chromosome: | 16q24.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19780 |
| Percent of cancer specimens with mutations: | 0.87 |
| Normal role description: | KIAA0182 is not well characterized but may function as a component of the BHC histone deacetylase complex involved in epigenetic modifications of chromatin. Mis-sense and Silent mutations have been observed in gastrointestinal and ovarian cancers but their functional effect has not been characterized. |
| Commentary on involvement of protein in cancer: | No entry in Atlasgeneticsoncology.org |