Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MVP |
| Gene Name: | MVP |
| Protein Full Name: | Major vault protein |
| Alias: | LRP; Lung resistance-related protein; VAULT1 |
| Mass (Da): | 99327 |
| Number AA: | 893 |
| UniProt ID: | Q14764 |
| Locus ID: | 9961 |
| COSMIC ID: | MVP |
| Gene location on chromosome: | 16p11.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.73 |
| Normal role description: | MVP is a transport protein involved in bi-directional nucleocytoplasmic transport of a wide range of substrate both vesicular and cytoplasmic. It may be responsible for drug resistance and lead to poor response to chemotherapy. It can mediate signal transduction by acting as a scaffolding protein and down regulate INFG mediated STAT1 signalling, downregulation of SRC through MAPK, and activation of JAK. |