Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CHD4 |
| Gene Name: | CHD4 |
| Protein Full Name: | Chromodomain-helicase-DNA-binding protein 4 |
| Alias: | Chromodomain helicase DNA binding protein 4; Chromodomain helicase-DNA-binding protein 4; Mi-2 autoantigen 218 kDa protein; Mi-2b; Mi2-beta |
| Mass (Da): | 217991 |
| Number AA: | 1912 |
| UniProt ID: | Q14839 |
| Locus ID: | 1108 |
| COSMIC ID: | CHD4 |
| Gene location on chromosome: | 12p13 |
| Number of cancer specimens: | 19743 |
| Percent of cancer specimens with mutations: | 1.39 |
| Commentary on involvement of protein in cancer: | Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. |