Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LASP1 |
| Gene Name: | LASP1 |
| Protein Full Name: | LIM and SH3 domain protein 1 |
| Alias: | LAS1; Lasp-1; LIM and SH3 protein 1; MLN 50; MLN50 |
| Mass (Da): | 29717 |
| Number AA: | 261 |
| UniProt ID: | Q14847 |
| Locus ID: | 3927 |
| COSMIC ID: | LASP1 |
| Gene location on chromosome: | 17q12-21 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20145 |
| Percent of cancer specimens with mutations: | 0.21 |
| Found in amplified chromosomal regions in human cancers: | amplified in 25% primary breast carcinomas |
| Deregulated in translocations: | MLL |
| Normal role description: | LASP1 is an actin binding protein and regulates dynamic cytoskeletal activities and cell motility. It is also involved in actin-associated transport activities in parietal cells and F-actin-rich secretory epithelial cells. It also has a role with nebulette and zyxin in organizing focal adhesions. Overexpression may lead to promote invasive phenotype and proliferation. |