Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STARD3 |
| Gene Name: | STARD3 |
| Protein Full Name: | StAR-related lipid transfer protein 3 |
| Alias: | CAB1; Metastatic lymph node protein 64; MLN 64; MLN64; STAR3; START domain-containing protein 3 |
| Mass (Da): | 50502 |
| Number AA: | 445 |
| UniProt ID: | Q14849 |
| Locus ID: | 10948 |
| COSMIC ID: | STARD3 |
| Gene location on chromosome: | 17q12-21 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.37 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | 17q11-q21 in 25% of breast carcinomas |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | STARD3 is a lipid transfer protein that binds and transports intracellular cholesterol for exporting. It may also promote steroidogenesis in the placenta and brain. A 17q11-q21 amplification is found in 25% of breast cancers and is associated with poor prognoses, but its role in oncogenesis is unknown. |