Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GPNMB |
| Gene Name: | GPNMB |
| Protein Full Name: | Transmembrane glycoprotein NMB |
| Alias: | Transmembrane glycoprotein HGFIN |
| Mass (Da): | 63923 |
| Number AA: | 572 |
| UniProt ID: | Q14956 |
| Locus ID: | 10457 |
| COSMIC ID: | GPNMB |
| Gene location on chromosome: | 7p15 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19690 |
| Percent of cancer specimens with mutations: | 0.68 |
| Normal role description: | GPNMB is involved in binding to heparin sulfate and integrins and is involved in cell-cell contact; also involved in normal melanogenesis. Different cancer models have determined both upregulation and downregulation to correlate with advancing stage of tumour progression potentially related to its organ-specific role and function. |