Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NUMA1 |
| Gene Name: | NUMA1 |
| Protein Full Name: | Nuclear mitotic apparatus protein 1 |
| Alias: | Nuclear mitotic apparatus protein 1: SP-H antigen: NUMA1 variant protein: Nuclear mitotic apparatus protein 1: SP-H antigen; NuMA protein |
| Mass (Da): | 238260 |
| Number AA: | 2115 |
| UniProt ID: | Q14980 |
| Locus ID: | 4926 |
| COSMIC ID: | NUMA1 |
| Gene location on chromosome: | 11q13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19906 |
| Percent of cancer specimens with mutations: | 1.34 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | t(11;17)(q13;q21) translocation with RARA in acute non-lymphoblastic leukemia |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | NUMA1 may be a spindle protein involved in the nuclear structure. It may play a role in mitotic spindle formation. Its function in cancer is unknown, but a t(11;17)(q13;q21) translocation with RARA has been associated with acute non-lymphoblastic leukemia (only 1 case). |